Rao, Manchanahalli S. ; Rothblum, Lawrence I. ; Busch, Harris (1978) Presence of elongation factor 1 in nuclei and nucleoli of rat liver Cell Biology International Reports, 2 (1). pp. 25-32. ISSN 0309-1651
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/030916...
Related URL: http://dx.doi.org/10.1016/0309-1651(78)90081-4
Abstract
Purified rat liver nuclei contain 11% of the total cellular translation elongation factor 1 activity. Ninety percent of the nuclear EF-1 activity was in the nucleoplasm and 10% was nucleolar. The specific activities of the nuclear and nucleolar EF-1 were 2 to 3 times higher, respectively, than EF-1 activity of the liver homogenate. The presence of EF-1 in the purified nuclei did not result from cytoplasmic contamination since only 0.14% of the cellular lactate dehydrogenase was present in the nuclei. These results provide the first evidence for the presence in the cell nucleus of translational factors of protein synthesis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 42510 |
| Deposited On: | 04 Jun 2011 10:13 |
| Last Modified: | 04 Jun 2011 10:13 |
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