CpG islands in chromatin organization and gene expression

Kundu, Tapas K. ; Rao, M. R. S. (1999) CpG islands in chromatin organization and gene expression The Journal of Biochemistry, 125 (2). pp. 217-222. ISSN 0021-924X

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Official URL: http://jb.oxfordjournals.org/content/125/2/217.sho...


CpG islands are stretches of DNA sequence that are enriched in the (CpG)n repeat and are present in close association with all housekeeping genes as well as some tissue-specific genes in the mammalian genome. Methylation of CpG islands strongly influences both structural organization and function of chromatin. The presence of a CpG island in a given chromosomal domain can, by itself, give rise to relatively open and active chromatin. Recently, several histone acetyltransferases, histone deacetylases, and chromatin remodeling factors have been found to be part of the transcription machinery. It is becoming increasingly clear that CpG islands and their methylation status may influence the function or recruitment of these newly discovered chromatin remodeling factors, especially the histone deacetylases. In addition, CpG islands may also play a significant role in the reorganization of chromatin during mammalian spermiogenesis.

Item Type:Article
Source:Copyright of this article belongs to Oxford University Press.
Keywords:Chromatin Remodeling; DNA Methylation; Histone Acetylation and Deacetylation; Spermiogenesis; Transition Proteins
ID Code:42493
Deposited On:04 Jun 2011 09:17
Last Modified:04 Jun 2011 09:17

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