Sanghamitra, Nusrat J. M. ; Varghese, Neenu ; Rao, C. N. R. (2010) Effect of curcumin and Cu2+/Zn2+ ions on the fibrillar aggregates formed by the amyloid peptide and other peptides at the organic-aqueous interface Chemical Physics Letters, 496 (1-3). pp. 104-108. ISSN 0009-2614
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.cplett.2010.07.017
Abstract
Characteristic features of a perilous neuro-degenerative disease such as the Alzhiemer's disease is fibrillar plaque formation by the amyloid (Aβ) peptide. We have modelled the formation and disintegration of fibrils by studying the aggregate structures formed by Aβ structural motif diphenylalanine as well as insulin and bovine serum albumin at the organic-aqueous interface. Even small concentrations of curcumin in the organic medium or Cu2+ and Zn2+ ions in the aqueous medium are found to break down the fibrillar structures.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 42402 |
| Deposited On: | 02 Jun 2011 13:15 |
| Last Modified: | 02 Jun 2011 13:15 |
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