Woodward, R. B. ; Logusch, E. ; Nambiar, K. P. ; Sakan, K. ; Ward, D. E. ; Au-Yeung, B. W. ; Balaram, P. ; Browne, L. J. ; Card, P. J. ; Chen, C. H. (1981) Asymmetric total synthesis of erythromycin. 3. Total synthesis of erythromycin Journal of the American Chemical Society, 103 (11). pp. 3215-3217. ISSN 0002-7863
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Official URL: http://pubs.acs.org/doi/abs/10.1021/ja00401a051
Related URL: http://dx.doi.org/10.1021/ja00401a051
Abstract
In the preceding paper' we described the preparation of the key lactone intermediate la in optically active form. In this paper we report the synthesis of erythromycin (2) from la. In essence,this transformation involves the glycosidation of a suitable derivative of la with L-cladinose and D-desosamine and the generation of the C-9 ketone functionality.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 4160 |
| Deposited On: | 18 Oct 2010 09:19 |
| Last Modified: | 16 May 2011 09:12 |
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