Molecular sieves-supported palladium(II) catalyst: Suzuki coupling of chloroarenes and an easy access to useful intermediates for the synthesis of irbesartan, losartan and boscalid

Abstract

Palladium(II) chloride supported on 4 Å molecular sieves efficiently catalyzes the Suzuki coupling reactions of chlorobenzenes in presence of tetrabutylammonium bromide without any ligand. The useful intermediates for the synthesis of bioactive compounds such as irbesartan, and losartan have been prepared in one step following this reaction. The preparation of this catalyst is very simple. The FE-SEM image shows a cube shape ordered structure. The catalyst does not exhibit any nanoparticles as indicated by TEM. EDS and XPS demonstrate anchoring of Pd on molecular sieves in +2 oxidation state. This heterogeneous catalyst is stable, non-air sensitive and recyclable.