Ray, P. K. ; Thakur, V. S. ; Sundaram, K. (1975) Antitumour immunity - 1. Differential response of neuraminidase-treated and X-irradiated tumour vaccine European Journal of Cancer (1965), 11 (1). pp. 1-8. ISSN 0014-2964
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/001429...
Related URL: http://dx.doi.org/10.1016/0014-2964(75)90030-4
Abstract
A dimethyl-benz-dithionapthene-induced fibrosarcoma shows reduced transplantability in syngeneic Swiss mice when treated with Vibrio cholerae neuraminidase (VCN). Reduced transplantability of fibrosarcoma has also been observed if they are X-irradiated. Inoculation of VCN treated cells leads to the development of strong antitumour immunity, whereas comparable results are not obtained with X-irradiated cells. However, inoculation of cells treated with VCN followed by X-irradiation can also establish lasting antitumour immunity. It is suggested that 'tumour vaccine' produced in this way may be very effective for the immunotherapy of tumour.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
ID Code: | 40759 |
Deposited On: | 25 May 2011 05:39 |
Last Modified: | 25 May 2011 05:39 |
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