Nikolics, Károly ; Mason, Anthony J. ; Sznyi, Éva ; Ramachandran, J. ; Seeburg, Peter H. (1985) A prolactin-inhibiting factor within the precursor for human gonadotropin-releasing hormone Nature, 316 . pp. 511-517. ISSN 0028-0836
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Official URL: http://www.nature.com/nature/journal/v316/n6028/ab...
Related URL: http://dx.doi.org/10.1038/316511a0
Abstract
The cloned complementary DNA sequence encoding the human gonadotropin-releasing hormone (GnRH) precursor protein was used to construct an expression vector for the bacterial synthesis of the 56-amino acid GnRH-associated peptide (GAP). GAP was found to be a potent inhibitor of prolactin secretion and to stimulate the release of gonadotropins in rat pituitary cell cultures. Active immunization with peptides corresponding to GAP sequences led to greatly increased prolactin secretion in rabbits.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Nature Publishing Group. |
| ID Code: | 40720 |
| Deposited On: | 25 May 2011 05:26 |
| Last Modified: | 25 May 2011 05:26 |
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