Ullrich, A. ; Bell, J. R. ; Chen, E. Y. ; Herrera, R. ; Petruzzelli, L. M. ; Dull, T. J. ; Gray, A. ; Coussens, L. ; Liao, Y. -C. ; Tsubokawa, M. ; Mason, A. ; Seeburg, P. H. ; Grunfeld, C. ; Rosen, O. M. ; Ramachandran, J. (1985) Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes Nature, 313 . pp. 756-761. ISSN 0028-0836
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Official URL: http://www.nature.com/nature/journal/v313/n6005/ab...
Related URL: http://dx.doi.org/10.1038/313756a0
Abstract
We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor α-subunit, a precursor processing enzyme cleavage site, then the β-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Nature Publishing Group. |
| ID Code: | 40716 |
| Deposited On: | 25 May 2011 05:26 |
| Last Modified: | 25 May 2011 05:26 |
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