Ravindranath, Vijayalakshmi ; Anandatheerthavarada, Hindupur K. ; Shankar, Susarla K. (1989) Xenobiotic metabolism in human brain- presence of cytochrome P-450 and associated mono-oxygenases Brain Research, 496 (1-2). pp. 331-335. ISSN 0006-8993
Full text not available from this repository.
Official URL: http://linkinghub.elsevier.com/retrieve/pii/000689...
Related URL: http://dx.doi.org/10.1016/0006-8993(89)91083-4
Abstract
The cytochromes P-450, a family of heme proteins, play an important role in the oxidation of drugs and carcinogens, as well as endogenous substrates. We report the presence of cytochrome P-450 and associated mono-oxygenase activity in human brain regions and their selective enrichment in the brainstem. Immunocytochemical studies on human medulla with antibodies raised to phenobarbital-inducible rat liver cytochrome P-450 indicate that the enzyme is primarily localized in the neuronal cell bodies and to a lesser extent in the axons. These observations indicate that the human brain could be involved in metabolism of xenobiotics and endogenous compounds, mediated through cytochrome P-450.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Human Brain; Xenobiotic Metabolism; Mono-oxygenase; Cytochrome P-450; Immunocytochemical Localization |
| ID Code: | 40569 |
| Deposited On: | 24 May 2011 13:21 |
| Last Modified: | 24 May 2011 13:21 |
Repository Staff Only: item control page
