Kikuchi, Norio ; Ehrlicher, Allen ; Koch, Daniel ; Käs, Josef A. ; Ramaswamy, Sriram ; Rao, Madan (2009) Buckling, stiffening, and negative dissipation in the dynamics of a biopolymer in an active medium PNAS, 106 (47). pp. 19776-19779. ISSN 0027-8424
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Official URL: http://www.pnas.org/content/106/47/19776.short
Related URL: http://dx.doi.org/10.1073/pnas.0900451106
Abstract
We present a generic theory for the dynamics of a stiff filament under tension, in an active medium with orientational correlations, such as a microtubule in contractile actin. In sharp contrast to the case of a passive medium, we find the filament can stiffen, and possibly oscillate or buckle, depending on both the contractile or tensile nature of the activity and the filament-medium anchoring interaction. We also demonstrate a strong violation of the fluctuation-dissipation (FD) relation in the effective dynamics of the filament, including a negative FD ratio. Our approach is also of relevance to the dynamics of axons, and our model equations bear a remarkable formal similarity to those in recent work [Martin P, Hudspeth AJ, Juelicher F (2001) Proc Natl Acad Sci USA 98:14380-14385] on auditory hair cells. Detailed tests of our predictions can be made by using a single filament in actomyosin extracts or bacterial suspensions.
Item Type: | Article |
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Source: | Copyright of this article belongs to National Academy of Sciences. |
Keywords: | Cytoskeleton; Active Hydrodynamics; Microrheology; Fluctuation-dissipation Ratio; Neuronal Growth Cone |
ID Code: | 40158 |
Deposited On: | 21 May 2011 10:45 |
Last Modified: | 17 May 2016 22:20 |
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