Mahanty, Sanjoy Kumar ; Khaware, Rajkishor ; Ansari, Shehnaz ; Gupta, Poonam ; Prasad, Rajendra (1991) Vanadate-resistant mutants of Candida albicans show alterations in phosphate uptake FEMS Microbiology Letters, 84 (2). pp. 163-166. ISSN 0378-1097
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1574-...
Related URL: http://dx.doi.org/10.1111/j.1574-6968.1991.tb04590.x
Abstract
Phosphate uptake studies in different strains of the dimorphic pathogenic yeast Candida albicans were undertaken to show that this yeast actively transported phosphate with an apparent Km in the range of 90-170 µM. The uptake was pH dependent and derepressible under phosphate starvation. Vanadate-resistant (van) mutants of C. albicans showed a 20-70% reduction in the rate of phosphate uptake in high phosphate medium and was associated with an increased Km and reduced Vmax. The magnitude of depression under phosphate starvation was different between van mutants. These results demonstrate that van mutants may have developed resistance by modifying the rate of entry of vanadate.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | Candida albicans; Vanadate-resistant Mutants; Plasma Membrane ATPase; Phosphate Transport |
| ID Code: | 39380 |
| Deposited On: | 12 May 2011 07:13 |
| Last Modified: | 12 May 2011 07:13 |
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