Synthesis of 1-β-D-Ribofuranosyl-5-ethoxycarbonyl-4- hydroxy -l,2-dihydropyrid-2-one

Abstract

I-β-D-Ribofuranosyl-5-ethoxycarbonyl-4-hydroxy-1,2-dihydropyrid-2-one has been synthesized starting from 2,4-dihydroxy-5-ethoxycarbonylpyridine. The monomercury derivative of the starting compound on condensation with 2,3,5-tri-O-benzoylribofuranosyl chloride affords benzoylated nucleoside which on debenzoylation in the presence of catalytic amount of sodium methoxide in the methanol furnishes the desired nucleoside.