Mukherjee, Anita ; Talukder, Geeta ; Sharma, Archana (1989) Sister chromatid exchanges induced by tertiary butyl hydroquinone in bone marrow cells of mice Environmental and Molecular Mutagenesis, 13 (3). pp. 234-237. ISSN 0893-6692
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/em.2850...
Related URL: http://dx.doi.org/10.1002/em.2850130307
Abstract
Tertiary butyl hydroquinone (TBHQ)-a phenolic antioxidant, was evaluated by assessing the induction of sister chromatid exchanges (SCEs) in bone marrow metaphase cells of mice. Six concentrations, 0.5, 2, 20, 50, 100, and 200 mg/kg, of TBHQ were injected intraperitoneally. A positive dose-response effect in the SCE frequency was observed using the Cochran-Armitage trend test. Two mg/kg of TBHQ was found to be the minimum effective dose. Study of the cell-cycle kinetics showed a delay in cell cycle induced by the higher concentrations of TBHQ. Thus, TBHQ was found to be a DNA damage-inducing agent and also a cytotoxic chemical in vivo in mice.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | in vivo Mouse; Antioxidant; Trend Test |
| ID Code: | 39032 |
| Deposited On: | 06 May 2011 09:40 |
| Last Modified: | 06 May 2011 09:40 |
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