Applications of liver acetone powders in enantioselective synthesis

Abstract

Applications of liver acetone powders (crude enzymes) as possible substitutes for purified enzyme preparations, hydrolases, in enantioselective organic transformations have been systematically investigated. (1R, 2R)-2-(4-Alkylphenoxy)cyclohexan-1-ols, (1R, 2R)- & (1S, 2S)- 2-nitroxycyclohexan-1-ols, (1R, 2S)-2-arylcyclohexan-1-ols, (3R, 4R)-6-methyl-3-phenylhept-1- en-4-ol, and (R)-1-(naphth-1-yl)ethanol have been synthesized in enantiomerically pure form via the enantioselective hydrolysis of the corresponding racemic acetates mediated by liver acetone powders.