Giri, Ashok Kumar ; Banerjee, Tara Shankar ; Talukder, Geeta ; Sharma, Archana (1986) Effects of dyes (Indigo Carmine, Metanil Yellow, Fast Green FCF) and nitrite in vivo on bone marrow chromosomes of mice Cancer Letters, 30 (3). pp. 315-320. ISSN 0304-3835
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/030438...
Related URL: http://dx.doi.org/10.1016/0304-3835(86)90056-X
Abstract
Effects of 3 dyes in combination with nitrite were studied on bone marrow chromosomes of mice following prolonged oral treatment. The dyes were namely, Indigo Carmine and Metanil Yellow, both of which contain a secondary amino group, and Fast Green FCF, which has a tertiary amino group. All dyes produced aberrations but Metanil Yellow showed stronger clastogenic activity than Fast Green FCF and Indigo Carmine. Nitrite alone also induced strong clastogenic activity. A combination of dye and nitrite half the normal concentrations produced synergistic effects, which may be ascribed to the formation of nitrosamines.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 38989 |
| Deposited On: | 05 May 2011 13:41 |
| Last Modified: | 05 May 2011 13:41 |
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