Asymmetric synthesis of (R)-3,3-dimethyl-2-hydroxy-γ-butyrolactone en route to the formal synthesis of calcium D-pantothenate

Rama Rao, A. V. ; Mahender Rao, S. ; Sharma, G. V. M. (1994) Asymmetric synthesis of (R)-3,3-dimethyl-2-hydroxy-γ-butyrolactone en route to the formal synthesis of calcium D-pantothenate Tetrahedron Letters, 35 (31). pp. 5735-5738. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4039(00)77292-3

Abstract

An efficient asymmetric protocol for the synthesis of (R)-3,3-dimethyl-2-hydroxy-γ-butyrolactone, a crucial intermediate for the synthesis of calcium D-pantothenate and several other compounds is described, where the requisite chirality is incorporated by Sharpless asymmetric epoxidation reaction.

Item Type:Article
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ID Code:38911
Deposited On:05 May 2011 09:00
Last Modified:05 May 2011 09:00

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