First enantioselective synthesis of mikanecic acid via Diels-Alder cycloaddition mediated construction of chiral vinylic quaternary center

Basavaiah, Deevi ; Pandiaraju, Subramanian ; Sarma, Pakala K. S. (1994) First enantioselective synthesis of mikanecic acid via Diels-Alder cycloaddition mediated construction of chiral vinylic quaternary center Tetrahedron Letters, 35 (24). pp. 4227-4230. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4039(00)73158-3

Abstract

Chiral mikanecic acid (1) was synthesized in 74% enantiomeric purity (92% ee after crystallization) via asymmetric Diels-Alder reaction of a novel in situ generated chiral 1,3-butadiene-2-carboxylate (A).

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