Rama Rao, A. V. ; Gurjar, M. K. ; Lalitha, S. V. S. ; Tripathy, Sasmita (1994) Anti-AIDS compounds: a new synthesis of β-thymidine from D-xylose Proceedings of the Indian Academy of Sciences - Chemical Sciences, 106 (6). pp. 1415-1421. ISSN 0253-4134
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Official URL: http://www.ias.ac.in/j_archive/chemsci/106/vol106c...
Related URL: http://dx.doi.org/10.1007/BF02840698
Abstract
β-Thymidine is a key intermediate in the manufacturing of anti-AIDS agents- AZT and d4 T. A practical and economically viable route to β-thymidine starting from inexpensive D-xylose has been described. This synthetic route is based on a new rearrangement leading to 2,2'-anhydro-formation with concomitant epimerisation at C-3', observed for the first time in nucleoside chemistry.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Indian Academy of Sciences. |
| Keywords: | 3'-Azido-3'-deoxy-β-thymidine; β-Thymidine; D-Xylose; Anti-AIDS Agents |
| ID Code: | 38867 |
| Deposited On: | 05 May 2011 07:17 |
| Last Modified: | 11 Jul 2012 03:45 |
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