Synthesis of a novel C2-symmetrical (2S,5S)-2,5-bis-[(1,1-dimethylethoxy)carbonylamino]-1,6-diphenylhex-3-ene: applications in the synthesis of potential HIV protease inhibitors

Rama Rao, A. V. ; Gurjar, Mukund K. ; Pal, Shashwati ; Pariza, Richard J. ; Chorghade, Mukund S. (1995) Synthesis of a novel C2-symmetrical (2S,5S)-2,5-bis-[(1,1-dimethylethoxy)carbonylamino]-1,6-diphenylhex-3-ene: applications in the synthesis of potential HIV protease inhibitors Tetrahedron Letters, 36 (14). pp. 2505-2508. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/004040...

Related URL: http://dx.doi.org/10.1016/0040-4039(95)00255-B

Abstract

The synthesis of a novel and versatile (2S,5S)-2,5-bis-[(1,1'-dimethylethoxy)carbonylamino]-1,6-diphenylhex-3-ene (2) based on Julia's olefination strategy coupled with its application in stereoselective preparations of HIV protease inhibitors has been discussed.

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