Basavaiah, Deevi ; Reddy, Gone Jayapal ; Chandrashekar, Vanampally (2002) (2S,5S)-1,3-Diaza-2-phospha-2-oxo-2-chloro-3-phenylbicyclo[3.3.0]octane: a novel chiral source for borane-mediated catalytic chiral reductions Tetrahedron: Asymmetry, 13 (11). pp. 1125-1128. ISSN 0957-4166
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09574...
Related URL: http://dx.doi.org/10.1016/S0957-4166(02)00263-X
Abstract
(2S,5S)-1,3-Diaza-2-phospha-2-oxo-2-chloro-3-phenylbicyclo[3.3.0]octane has been successfully employed as a chiral catalytic source for the borane mediated asymmetric reductions of prochiral α-halo ketones to provide the desired (S)-secondary alcohols in 81-91% enantiomeric purities, thus for the first time demonstrating the potential of the N-P(=O)Cl structural framework to generate a recoverable, reusable and air stable catalyst for the asymmetric reduction processes.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 3862 |
| Deposited On: | 18 Oct 2010 09:35 |
| Last Modified: | 17 Jan 2011 05:01 |
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