Roice, M. ; Rajasekharan Pillai, V. N. (2003) Kinetics of amide formation on 1,4-butanediol dimethacrylate crosslinked polystyrene resin: a comparison with PS-DVB resin Journal of Applied Polymer Science, 88 (13). pp. 2897-2903. ISSN 0021-8995
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/app.119...
Related URL: http://dx.doi.org/10.1002/app.11933
Abstract
An efficient crosslinked polymer support was synthesized by introducing 1,4-butanediol dimethacrylate crosslinker to a polystyrene network using aqueous suspension polymerization technique. The support was functionalized with aminomethyl groups using chloromethyl phthalimide. The kinetics of amide bond formation on 1,4-butanediol dimethacrylate crosslinked polystyrene (PS-BDODMA) polymer were carried out using the attachment of Rink amide linker as a model reaction. The efficiency of the support was tested and compared with Merrifield resin by following different steps involved in the synthesis of a 14-residue model peptide, Lys-Ile-Asn-Thr-Asn-Ala-Ser-Trp-His-Ala-Asn-Arg-Thr-Ala-NH2, under the same synthetic conditions.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | Kinetics; Peptides; Synthesis; Resins |
| ID Code: | 38619 |
| Deposited On: | 23 May 2011 07:58 |
| Last Modified: | 23 May 2011 07:58 |
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