Arunan, C. ; Rajasekharan Pillai, V. N. (2003) 1,6-hexanediol diacrylate-crosslinked polystyrene: preparation, characterization, and application in peptide synthesis Journal of Applied Polymer Science, 87 (8). pp. 1290-1296. ISSN 0021-8995
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/app.115...
Related URL: http://dx.doi.org/10.1002/app.11538
Abstract
A copolymer of 1,6-hexanediol diacrylate (HDODA) and styrene was prepared by a suspension polymerization method. The resin was characterized by infrared and carbon-13 cross-polarization magic-angle spin (13C CP-MAS) spectroscopy. The topology of the resin was examined by scanning electron microscopy (SEM). The polymer swells extensively in common solvents used for peptide synthesis. The resin exhibited chemical stability even in neat trifluoroacetic acid. The applicability of the new resin was demonstrated by synthesis of Val-Ala-Val-Ala-Ala-Gly, Gln-Val-Gly-Gln-Val-Glu-Leu-Gly, and Val-Gln-Ala-Ala-Ile-Asp-Tyr-Ile-Asn-Gly. Comparative synthetic studies showed that the new resin is superior to divinylbenzene (DVB)-based resin in the case of the synthesis of hydrophobic peptide sequences.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | Resins; Peptides; Polystyrene; Polymerization |
| ID Code: | 38616 |
| Deposited On: | 23 May 2011 07:58 |
| Last Modified: | 23 May 2011 07:58 |
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