Shankaranarayana Rao, B. S. ; Lakshmana, M. K. ; Meti, B. L. ; Raju, T. R. (1999) Chronic (−) deprenyl administration alters dendritic morphology of layer III pyramidal neurons in the prefrontal cortex of adult Bonnett monkeys Brain Research, 821 (1). pp. 218-223. ISSN 0006-8993
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/s0006-...
Related URL: http://dx.doi.org/10.1016/S0006-8993(98)01362-6
Abstract
Chronic (−) deprenyl (0.2 mg/kg, b.wt; for 25 days) treatment induced alterations in the dendritic morphology of prefrontal cortical neurons in adult Bonnett monkeys were evaluated in the present study. The branching points and intersections in apical and basal dendrites were studied up to a distance of 400 and 200 µm, respectively, in Golgi impregnated layer III pyramidal neurons of the prefrontal cortex. Our results revealed a significant (P<0.001) increase in the number of branching points and intersections in both apical and basal dendrites in (−) deprenyl treated monkeys compared to controls. Such an enriched dendritic arborization in prefrontal cortical neurons may be responsible for the enhancement of cognitive functions in Alzheimer disease patients following (−) deprenyl treatment.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | (−) Deprenyl; Monkey Prefrontal Cortex; Layer III Pyramidal Neuron; Dendritic Arborization; Golgi Staining; Neural Plasticity |
| ID Code: | 38545 |
| Deposited On: | 23 May 2011 14:31 |
| Last Modified: | 23 May 2011 14:31 |
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