Enhancement in anti-semliki forest virus activity of ds RNA by a muramyl dipeptide

George, C. X. ; Jain, R. K. ; Gupta, C. M. ; Anand, Nitya (1986) Enhancement in anti-semliki forest virus activity of ds RNA by a muramyl dipeptide FEBS Letters, 200 (1). pp. 37-41. ISSN 0014-5793

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/001457...

Related URL: http://dx.doi.org/10.1016/0014-5793(86)80506-3

Abstract

Antiviral activity of an interferon-inducing mycoviral ds RNA against Semliki Forest virus infection was considerably enhanced by N-palmitoylmuramyl-L-alanyl-D-isoglutamine (PMDP), a new muramyl dipeptide. This enhancement in activity was not due to increased production of interferon, but resulted probably from a PMDP-induced increase in nonspecific resistance to infection. These results indicate that a combined treatment with an interferon inducer and muramyl dipeptide may prove highly useful to control effectively viral infections.

Item Type:Article
Source:Copyright of this article belongs to Federation of European Biochemical Societies.
Keywords:Viral Infection; Interferon; Inducer; Muramyl Dipeptide; Macrophage Activation
ID Code:3824
Deposited On:18 Oct 2010 09:41
Last Modified:16 May 2016 14:33

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