A near-infrared squaraine dye as a latent ratiometric fluorophore for the detection of aminothiol content in blood plasma

Sreejith, Sivaramapanicker ; Divya, Kizhumuri P. ; Ajayaghosh, Ayyappanpillai (2008) A near-infrared squaraine dye as a latent ratiometric fluorophore for the detection of aminothiol content in blood plasma Angewandte Chemie International Edition, 47 (41). pp. 7883-7887. ISSN 1433-7851

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Official URL: http://www3.interscience.wiley.com/journal/1214025...

Related URL: http://dx.doi.org/10.1002/anie.200803194

Abstract

Hunt for thiols: A nucleophilic thiol attack on a weakly fluorescent near-infrared (NIR) squaraine dye results in a conjugation break to form an adduct that absorbs in the UV/Vis region and is highly fluorescent. This fluorophore allows the selective detection of thiols either by colorimetry or fluorescence (see picture). The probe is suitable for the detection and estimation of the total aminothiol content in human blood plasma.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:Fluorophores; Luminescence; Molecular Probes; Sensors; Squaraine Dyes
ID Code:378
Deposited On:21 Sep 2010 04:44
Last Modified:31 Dec 2010 05:18

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