Balraju, V. ; Srinivasa Reddy, D. ; Periasamy, Mariappan ; Iqbal, Javed (2005) Synthesis of small cyclic peptides constrained with 3-(3-aminomethylphenyl)propionic acid linkers using free radical-mediated macrocyclization Tetrahedron Letters, 46 (31). pp. 5207-5210. ISSN 0040-4039
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...
Related URL: http://dx.doi.org/10.1016/j.tetlet.2005.05.115
Abstract
In this letter, we report that small peptides (di- and tri-) having a 3-bromobenzyl group at the C-termini and an acryloyl group at the N-termini undergo an efficient Bu3SnH–AIBN mediated intramolecular free radical cyclization to afford cyclic peptides in good yields. We also propose that these cyclizations are occurring via a pre-organized acyclic structure dictated by a reverse turn (γ/β-turn).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Peptidomimetics; Free Radical; Cyclic Peptide |
| ID Code: | 37263 |
| Deposited On: | 25 Apr 2011 08:07 |
| Last Modified: | 11 Jul 2012 04:34 |
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