Efficient resolution of (±)-trans-2,3-diphenylpiperazine using (1S)-(+)-10-camphorsulfonic acid and enrichment of enantiomeric purity of non-racemic 2,3-diphenylpiperazine using different achiral acids

Vairaprakash, Pothiappan ; Periasamy, Mariappan (2008) Efficient resolution of (±)-trans-2,3-diphenylpiperazine using (1S)-(+)-10-camphorsulfonic acid and enrichment of enantiomeric purity of non-racemic 2,3-diphenylpiperazine using different achiral acids Proceedings of the Indian Academy of Sciences - Chemical Sciences, 120 (1). pp. 175-179. ISSN 0253-4134

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Related URL: http://dx.doi.org/10.1007/s12039-008-0020-5

Abstract

Enantiomerically pure (R,R)-(+)-2,3-diphenylpiperazine with 98% ee was obtained by resolution of the corresponding racemic mixture using (1S)-(+)-10-camphorsulfonic acid. The partially resolved enriched sample of (S,S)-(-)-2,3-diphenylpiperazine with 73% ee was purified to obtain samples of 97% ee using different achiral acids via the preparation of either homochiral or heterochiral hydrogen bonded aggregates.

Item Type:	Article
Source:	Copyright of this article belongs to Indian Academy of Sciences.
Keywords:	2,3-Diphenylpiperazine; Camphorsulfonic Acid; Resolution; Homochiral Aggregates; Heterochiral Aggregates
ID Code:	37259
Deposited On:	25 Apr 2011 08:08
Last Modified:	17 May 2016 20:10

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