Convenient methods for the reduction of amides, nitriles, carboxylic esters, acids and hydroboration of alkenes using NaBH4/I2system

Bhanu Prasad, A. S. ; Bhaskar Kanth, J. V. ; Periasamy, Mariappan (1992) Convenient methods for the reduction of amides, nitriles, carboxylic esters, acids and hydroboration of alkenes using NaBH4/I2system Tetrahedron, 48 (22). pp. 4623-4628. ISSN 0040-4020

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4020(01)81236-9

Abstract

Reaction of amides with NaBH4-I2 system in THF gives the corresponding amines in 70–76% yields. Reduction of nitriles yields the corresponding amines in 70–75% yields. The I2/NaBH4 system is useful in the hydrocarboration of olefins and the corresponding alcohols are obtained in 78–92% yields after H2O2/OH- oxidation. The reagent system is also useful for the reduction of carboxylic esters and acids to the corresponding alcohols in 60-90% yields.

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