Bir, Nivedita ; Paliwal, Anubha ; Muralidhar, K. ; Sarma, P. Usha (1999) Biochemical characterization of an immunodominant allergen/antigen of Aspergillus fumigatus Indian Journal of Clinical Biochemistry, 14 (2). pp. 149-158. ISSN 0970-1915
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Official URL: http://www.springerlink.com/content/p55914417wp115...
Related URL: http://dx.doi.org/10.1007/BF02867913
Abstract
An 18kDa protein was identified as a major immunodominant allergen/antigen secreted by a wild type isolate and various clinical isolates of A. fumigatus. The protein was purified to homogeneity and the N-terminal amino acid was found to be alanine. The N-terminal 20 amino acid sequence of 18kDa was found to be similar to restrictocin, a cytotoxin secreted by Aspergillus restrictus. Mass spectroscopic analysis of the purified allergen revealed a molecular size of 17.01 kDa. Immunoreactivity of the purified allergen with monoclonal antibodies and specific IgG and IgE antibodies of the patients of aspergillosis confirmed that this protein is Asp fl.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Association of Clinical Biochemistry of India. |
| Keywords: | Aspergillus fumigatus ; Allergen; Antigen; 18kDa Antigen; RIA |
| ID Code: | 36386 |
| Deposited On: | 14 Apr 2011 14:14 |
| Last Modified: | 14 Apr 2011 14:14 |
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