Patil, M.S. ; Pradhan, D. S. ; Sreenivasan, A. (1975) Effect of whole-body irradiation on transcription in the rat thymus International Journal of Radiaton Biology, 27 (4). pp. 363-370. ISSN 0955-3002
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Official URL: http://informahealthcare.com/doi/abs/10.1080/09553...
Related URL: http://dx.doi.org/10.1080/09553007514550331
Abstract
Studies were carried out to elucidate the mechanism underlying the impairment in RNA synthesis in the rat thymus after whole-body exposure to X-rays (1000 rad). The ability of thymus nuclei to catalyse RNA polymerization in vitro was adversely affected in irradiated rats. Further experiments showed that whole-body irradiation caused a considerable decrease in both the activity of RNA polymerase and the template efficiency of chromatin but not in that of DNA isolated from chromatin. These radiation-induced changes in transcription seem to arise partly from the direct effect of radiation on the thymus itself and partly from the abscopal mechanism(s).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Informa plc. |
| ID Code: | 36025 |
| Deposited On: | 21 Apr 2011 13:52 |
| Last Modified: | 21 Apr 2011 13:52 |
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