Sulphanilamides. Part II. In vitro synergism with anionic surface-active compounds

Pavgi, M. S. ; Sane, V. C. ; Sreenivasan, A. ; Venkataraman, K. (1951) Sulphanilamides. Part II. In vitro synergism with anionic surface-active compounds Proceedings of the Indian Academy of Sciences, Section A, 33 (1). pp. 56-65. ISSN 0370-0089

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1. The bacteriostatic properties of sulphanilamide and five N1-substituted sulphanilamides, and of three anionic surface-active compounds, have been studied, singly and together, against the organisms, S. aureus, E. coli, and E. typhosa, using peptone-broth and a synthetic medium. 2. With incubation temperatures of 37° and 43° the concentration of sulphanilamide for bacteriostasis in peptone medium is independent of the age of the culture and the concentration of the inoculum at the higher temperature only. In the synthetic medium, the effects of age of cells and size of inocula are less pronounced at both temperatures of incubation. 3. The minimum effective concentrations of sulpha drugs needed for growth inhibition are more in peptone broth than in the synthetic medium. Similar but less pronounced differences are seen with the surface-active compounds against S. aureus. 4. While the surface-active compounds are by themselves ineffective against the Gram-negative organisms, they have potentiating activity with the sulpha drugs. 5. The synergic effects of sulphanilamide and surface-active compound are unaltered even when the organism is rendered resistant to sulphanilamide or when the antibacterial property of the surface-active compound is neutralized by lecithin.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
ID Code:35767
Deposited On:21 Apr 2011 10:26
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