Netticadan, T. J. ; Ashavaid , T. F. ; Nair, K. G. (1997) Characterisation of the canine cardiac sarcolemma in experimental myocardial ischemia Indian Journal of Clinical Biochemistry, 12 (1). pp. 49-54. ISSN 0970-1915
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Official URL: http://www.springerlink.com/content/yj44332n47576x...
Abstract
The cardiac sarcolemma was characterized in 13 normal and 11 ischemic dog hearts by enzyme analysis and compositional assays. Significant decreases in the activities of the sodium-potassium and calcium pumps and structural compositional disturbances were observed in ischemia. High concentrations of oleic acid, a fatty acid and palmitoyl carnitine, a fatty acid intermediate caused inhibition of the enzyme pump activities of the normal sarcolemma. Thus, ischemia results in the functional impairment of the sarcolemma. Accumulation of fatty acid and fatty acid intermediates, occurring in myocardial ischemia, could be an underlying mechanism.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Association of Clinical Biochemistry of India. |
| Keywords: | Myocardial Ischaemia: Canine Cardiac Sarcolemma |
| ID Code: | 35734 |
| Deposited On: | 09 Apr 2011 10:16 |
| Last Modified: | 09 Apr 2011 10:16 |
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