ACE and AT1R gene polymorphisms and hypertension in Indian population

Ashavaid, T. F. ; Shalia, K. K. ; Nair, K. G. ; Dalal, J. J. (2000) ACE and AT1R gene polymorphisms and hypertension in Indian population Journal of Clinical Laboratory Analysis, 14 (5). pp. 230-237. ISSN 0887-8013

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/1098-28...

Related URL: http://dx.doi.org/10.1002/1098-2825(2000)14:5<230

Abstract

The renin angiotensin system (RAS) controls intrarenal blood pressure and sodium balance, and is an important target for antihypertensive therapy. Several polymorphisms have been identified within genes encoding RAS that may contribute to the development of elevated blood pressure. The relevance of these polymorphisms in hypertension remains controversial. In this study we have examined 105 hypertensive subjects and 192 controls from the Indian population for I/D polymorphism of angiotensin I converting enzyme (ACE) and A1166C polymorphism of angiotensin II type I receptor (AT1R) genes by polymerase chain reaction (PCR) and PCR-based restriction enzyme analysis method, respectively. There was no significant difference in the distribution of ACE (I/I, I/D, and D/D) and AT1R (A/A and A/C) genotypes between controls and hypertensive subjects. D allele was significantly associated with an early onset of hypertension and although nonsignificant, the frequency was high in subjects with family history of cardiovascular disorders. C1166 allele of AT1R did not correlate with the age of onset of hypertension and the frequency was low in subjects with family history. Thus no association was found between ACE and AT1R genotypes and hypertension. However the D allele can be used as a predictor of risk of hypertension in the Indian population.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Renin Angiotensin System; Angiotensin II; Insertion/Deletion Polymorphism; A1166C Polymorphism; India
ID Code:35613
Deposited On:09 Apr 2011 10:21
Last Modified:19 Apr 2011 10:36

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