Rajagopalan, K. V. ; Udayachander, M. ; Sarma, P. S. (1960) Metabolic effects of isonicotinic acid hydrazide (INH) toxicity in Saccharomyces cerevisiae Archives of Biochemistry and Biophysics, 87 (2). pp. 184-187. ISSN 0003-9861
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000398...
Related URL: http://dx.doi.org/10.1016/0003-9861(60)90157-0
Abstract
The antitubercular drug, isonicotinic acid hydrazide (INH), has been found to inhibit the growth of Saccharomyces cerevisiae. A stress on the amine-acetylating system by INH is indicated in view of the increased sulfanilamide acetylase activity and enhanced coenzyme A levels of the yeast cells grown in the presence of growth-inhibiting levels of the drug. A concomitant increase in the ergosterol content of the treated cells has also been observed, indicating that sterol synthesis is highly sensitive to changes in coenzyme A levels. The implication of these results has been discussed in relation to the reported effects of INH toxicity in experimental animals and in patients.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 35339 |
| Deposited On: | 07 Apr 2011 12:24 |
| Last Modified: | 07 Apr 2011 12:24 |
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