Sundaram, T. K. ; Sarma, P. S. (1956) Metabolism of nicotinic acid under normal conditions and in pantothenate deficiency, studied in the rat Biochimica et Biophysica Acta, 22 (3). pp. 547-549. ISSN 0006-3002
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000630...
Related URL: http://dx.doi.org/10.1016/0006-3002(56)90066-X
Abstract
The metabolism of nicotinic acid in normal and pantothenate-deficient rats has been studied with particular reference to the excretion of nicotinuric acid, the glycine conjugate of nicotinic acid. It has been shown that, whereas nicotinuric acid constitutes about 60% of the tertiary derivatives of nicotinic acid excreted by control rats, it accounts for a markedly lower proportion of the tertiary derivatives in the case of the pantothenate-deficient animals. The results are interpreted to indicate an involvement of CoA in nicotinuric acid biosynthesis as in the enzymic synthesis of hippuric acid from benzoic acid and glycine.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 35336 |
| Deposited On: | 07 Apr 2011 09:28 |
| Last Modified: | 07 Apr 2011 09:28 |
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