Biswas, B. B. ; Abrams, Richard (1961) Formation of hypoxanthine from guanine in rat liver extracts Archives of Biochemistry and Biophysics, 92 (3). pp. 507-511. ISSN 0003-9861
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000398...
Related URL: http://dx.doi.org/10.1016/0003-9861(61)90391-5
Abstract
The formation of hypoxanthine from guanine in extracts of rat liver has been observed and its mechanism investigated. Evidence is presented indicating that the reduction occurs at the free base level, the pathway involving deamination to xanthine, reduction by DPNH and xanthine oxidase to hypoxanthine, and stabilization at the hypoxanthine oxidation level by conversion to inosinc in the presence of nucleoside phosphorylase. This pathway was confirmed in a model system with pure enzymes, DPNH, and a source of ribose 1-phosphate.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 3488 |
| Deposited On: | 12 Oct 2010 04:30 |
| Last Modified: | 19 May 2011 10:58 |
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