Kennady, P. Kavin ; Parnaik, Veena K. (1992) Incomplete splicing of simian virus 40 large T antigen transcripts in a transformed mouse cell line Virology, 190 (1). pp. 480-484. ISSN 0042-6822
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/004268...
Related URL: http://dx.doi.org/10.1016/0042-6822(92)91238-P
Abstract
The SV40 large T antigen transcripts from an SV40-transformed mouse embryo fibroblast cell line (215) have been analyzed by Northern blots and by mapping and sequencing of the corresponding cDNAs. We have observed that T antigen mRNA is highly overexpressed in the 215 cells, and is mostly unspliced, but there are no sequence changes at the splice sites. However, normal amounts of wild-type T antigen are produced, suggesting that the splicing and translation of T antigen RNA is tightly controlled in these cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 34809 |
| Deposited On: | 11 Apr 2011 14:00 |
| Last Modified: | 11 Apr 2011 14:00 |
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