Parnaik, Veena K. (1987) DNAase-I-hypersensitive sites in the mouse albumin gene Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 910 (1). pp. 27-33. ISSN 0167-4781
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/016747...
Related URL: http://dx.doi.org/10.1016/0167-4781(87)90091-1
Abstract
We have analyzed the DNAase I sensitivity of the mouse α-fetoprotein and albumin structural genes from fetal liver, adult liver and kidney. The albumin gene shows distinct hypersensitive sites in adult liver in addition to an overall DNAase I sensitivity, but is only slightly nuclease-sensitive in fetal liver. The α-fetoprotein gene does not show hypersensitive sites but displays an overall DNAase I sensitivity in fetal liver; however, it is nuclease-insensitive in adult liver. Both genes are insensitive to DNAase I in kidney. The presence of DNAase-I-hypersensitive sites in the albumin structural gene correlates with extensive demethylation of the gene in adult liver.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Chromatin; α-Fetoprotein Gene; Albumin Gene; Nuclease-sensitive Site; Transcription; DNA Methylation |
| ID Code: | 34783 |
| Deposited On: | 11 Apr 2011 14:00 |
| Last Modified: | 11 Apr 2011 14:00 |
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