Lakshmanan, J. ; Padmanaban, G. (1974) Effect of some “strong” excitants of central neurones on the uptake of L-glutamate and L-aspartate by synaptosomes Biochemical and Biophysical Research Communications, 58 (3). pp. 690-698. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00062...
Related URL: http://dx.doi.org/10.1016/S0006-291X(74)80473-0
Abstract
“Strong” excitants of central neurones such as β N-oxalyl L α,β-diaminopropionic acid (ODAP), N-methyl-D-aspartic acid (NMDA) and kainic acid (KA) were found to inhibit the high affinity uptake of glutamate and aspartate in synaptosomes isolated from young rat brain. The potency of these “strong” excitants as convulsants appear to parallel their ability to inhibit glutamate uptake by synaptosomes. The data suggest the possibility that the convulsive effect of these “strong” excitants could be mediated by glutamate/aspartate.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 34622 |
| Deposited On: | 18 Apr 2011 13:59 |
| Last Modified: | 18 Apr 2011 13:59 |
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