Surolia, N. ; Karthikeyan, G. ; Padmanaban, G. (1993) Involvement of cytochrome P450 in conferring chloroquine resistance to the malarial parasite, Plasmodium falciparum Biochemical and Biophysical Research Communications, 197 (2). pp. 562-569. ISSN 0006-291X
Full text not available from this repository.
Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00062...
Related URL: http://dx.doi.org/10.1006/bbrc.1993.2516
Abstract
The higher levels of cytochrone P-450 dependent enzyme activities reported earlier are traced to higher levels of cytochrome P-450 (CYPIIB1/B2 like) messenger RNA in the chloroquine resistant than the sensitive strains. The messenger RNA is also induced by phenobarbitone in the sensitive strain. Pretreatment with phenobarbitone affords partial protection to chloroquine toxicity in the sensitive strain and this is not due to a differential accumulation of the drug.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 34618 |
| Deposited On: | 18 Apr 2011 14:08 |
| Last Modified: | 09 Oct 2011 08:44 |
Repository Staff Only: item control page
