Surolia, Namita ; Padmanaban, Govindarajan (1992) De novo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite Biochemical and Biophysical Research Communications, 187 (2). pp. 744-750. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...
Related URL: http://dx.doi.org/10.1016/0006-291X(92)91258-R
Abstract
The human malarial parasite Plasmodium falcipuram, has been found to synthesize heme de novo, despite the accumulation of large quantities of polymeric heme derived from the hemoglobin of the red cell host. The parasite δ-aminolevulinate dehydrase level is significantly lower than that of the host and its inhibition by succinylacetone leads to inhibition of parasite protein synthesis and viability.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 34021 |
| Deposited On: | 18 Apr 2011 14:08 |
| Last Modified: | 09 Oct 2011 08:43 |
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