Padmanaban, G. ; Venkateswar, V. ; Rangarajan, P. N. (1989) Haem as a multifunctional regulator Trends in Biochemical Sciences, 14 (12). pp. 492-496. ISSN 0968-0004
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/096800...
Related URL: http://dx.doi.org/10.1016/0968-0004(89)90182-5
Abstract
Haem has long been known as the prosthetic group of haemoproteins such as haemoglobin, catalase and the cytochromes. Its biosynthesis is regulated by feedback mechanisms that ensure its adequate production but prevent its overaccumulation, which is highly deleterious as diseases such as porphyrias attest. However, recent years have seen rapid strides in our understanding of how haem (or more accurately haemin, its oxidized form) itself acts as an intracellular regulator of a variety of other metabolic pathways for systems that utilize oxygen.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 34019 |
| Deposited On: | 18 Apr 2011 14:07 |
| Last Modified: | 05 Jul 2012 09:35 |
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