Rangarajan, P. N. ; Ravishankar, H. ; Padmanaban, G. (1987) Isolation of a cytochrome P-450e gene variant and characterization of its 5' flanking sequences Biochemical and Biophysical Research Communications, 144 (1). pp. 258-263. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00062...
Related URL: http://dx.doi.org/10.1016/S0006-291X(87)80504-1
Abstract
A cytochrome P-450e gene variant has been isolated from the rat liver genomic library. It is a typical e gene clone but unique in having b-like single base substitutions at specific sites in the 5' flanking region. It also appears to have certain additional restriction sites in the introns. When compared with the cytochrome P-450b gene, the e gene has some of the repetitive motifs interrupted in the 5' flanking region. In addition, this region is characterized by the presence of alternating pyrimidine-purine stretch, steroid hormone regulatory elements, consensus eukaryotic enhancer sequence and sequences involved in general amino acid regulation.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 33676 |
| Deposited On: | 18 Apr 2011 14:04 |
| Last Modified: | 23 Jun 2012 11:34 |
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