Bhat, Kolari S. ; Padmanaban, G. (1978) Site of synthesis of cytochrome P-450 in liver Biochemical and Biophysical Research Communications, 84 (1). pp. 1-6. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...
Related URL: http://dx.doi.org/10.1016/0006-291X(78)90254-1
Abstract
The suggestion that a rapidly sedimenting rough endoplasmic reticulum fraction in close association with mitochondria, is the preferred site of cytochrome P-450 synthesis has been examined. The rate of cytochrome P-450 synthesis in the different subcellular fractions has been evaluated in vivo and in vitro, using the immunoprecipitation technique. The results indicate that the conventional microsomal fraction (100,000 X g sediment) is the major site of cytochrome P-450 synthesis and that the rapidly sedimenting rough endoplasmic reticulum fraction associated with mitochondria is not a preferred site for the hemoprotein synthesis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 33663 |
| Deposited On: | 18 Apr 2011 14:00 |
| Last Modified: | 18 Apr 2011 14:00 |
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