Fabiola, Gabriel F. ; Pattabhi, Vasantha ; Nagarajan, Kuppuswamy (1998) Structural basis for selective inhibition of COX-2 by nimesulide Bioorganic & Medicinal Chemistry, 6 (12). pp. 2337-2344. ISSN 0968-0896
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09680...
Related URL: http://dx.doi.org/10.1016/S0968-0896(98)80012-6
Abstract
Nimesulide 1 is a novel nonsteroidal antiinflammatory drug which inhibits the enzyme cyclooxygenase 2 (COX-2) more selectively than cyclooxygenase 1 (COX-1). Molecular modelling studies have been carried out on complexes of 1 with COX-1 and with mutants of COX-1 simulating COX-2. These indicate that the mutations I523V and S516A largely contribute to the selectivity. A comparative study with SC-558 2 has also been performed.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | NSAIDS; Selective Inhibition of COX-2; Computer Modelling; Nimesulide |
| ID Code: | 33411 |
| Deposited On: | 21 Mar 2011 14:27 |
| Last Modified: | 21 Mar 2011 14:27 |
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