Biological monitoring of bidi industry workers occupationally exposed to tobacco

Bhisey, Rajani A. ; Bagwe, Aparna N. ; Mahimkar, Manoj B. ; Buch, Shama C. (1999) Biological monitoring of bidi industry workers occupationally exposed to tobacco Toxicology Letters, 108 (2-3). pp. 259-265. ISSN 0378-4274

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Ambient and biological monitoring was undertaken among tobacco processors who are chronically exposed to tobacco particulates via nasopharyngeal and cutaneous routes. Ambient monitoring revealed that the inspirable dust concentration was 150-fold higher in the tobacco factory than in the control environment, and was associated with chronic bronchitis in workers. Increased systemic exposure to tobacco constituents was evident from the high levels of cotinine, thioethers, promutagens and direct acting mutagens in workers' urine. The mean glutathione level and glutathione S-transferase activity were significantly lower in the peripheral blood lymphocytes of workers; however, the frequency of the GSTM1 null allele was similar to that in controls. A significant increase in chromosomal damage was noted in target and non-target cells of tobacco processors. In view of the association between tobacco use and several non-communicable diseases, the findings of the present study indicate an urgent need to minimize tobacco exposure among the processors.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Bidi Tobacco; Occupation; Mutagenicity; Genotoxicity
ID Code:3231
Deposited On:11 Oct 2010 09:56
Last Modified:27 May 2011 09:17

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