Bhat, R. ; Ahluwalia, J. C. (1987) Effect of calcium chloride on the conformation of proteins International Journal of Peptide and Protein Research, 30 (2). pp. 145-152. ISSN 0367-8377
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Official URL: http://www3.interscience.wiley.com/journal/1214996...
Related URL: http://dx.doi.org/10.1111/j.1399-3011.1987.tb03323.x
Abstract
Partial molar heat capacities (C°) and volumes (V°) for some amino acids and peptides were measured in 1 M aqueous calcium chloride solutions at 298.15°K using a Picker flow microcalorimeter and an oscillating-tube digital density mater. Using the data for these amino acids and peptides in water, the corresponding partial capacities of transfer (C°) and volumes (V°) from water to 1 M aqueous calcium chloride were deduced. These thermodynamic parameters are significantly positive, indicating that strong interactions occur between the ions of calcium chloride and the charged centres of these amino acids and peptides. A comparison has been made with a similar transfer of these compounds to sodium chloride solutions. The thermodynamic parameters of the transfer of peptide group (-CONH) are much more positive in calcium chloride than in sodium chloride solutions. The implication of this result for the ability of calcium chloride to act as a stronger destabilizer of protein conformation is discussed.
Item Type: | Article |
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Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
Keywords: | Partial Molar Heat Capacity of Transfer; Partial Molar Volume of Transfer; Protein Denaturation; Transition Temperature |
ID Code: | 321 |
Deposited On: | 21 Sep 2010 04:49 |
Last Modified: | 11 May 2011 07:13 |
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