Maintenance of the epididymis in the castrated golden hamster by testosterone and dihydrotestosterone

Abstract

The responses of the epididymis and accessory glands of reproduction of the hamster to graded doses of testosterone and dihydrotestosterone were investigated. The caput and cauda epididymis and the sex accessories exhibit differential sensitivities to androgens with regard to both weight and secretory activity. The epididymis requires a higher threshold of androgen than the other accessory organs for the maintenance of its weight. Testosterone is more effective than dihydrotestosterone in maintaining growth responses in the caput epididymis, seminal vesicles and Cowper's glands. Continuous release of microquantities of testosterone and dihydrotestosterone from silastic capsules appears to maintain secretory activity better than parenteral administration of the hormones.