Inhibition of estrogen induced glycogen synthesis in the rat by clomiphene

Abstract

The effect of estradiol and/or clomiphene on blood glucose, uterine and liver glycogen was studied in the rat during delayed implantation. Estrogen induced a sharp increase in uterine glycogen at 6 hours while clomiphene caused a significant increase at 24 hours. Pretreatment with clomiphene inhibited estrogen induced glycogenesis. Estrogen administration resulted in a three fold increase in liver glycogen at 6 hours while clomiphene induced a two fold increase at 24 hours. Pretreatment with clomiphene completely blocked subsequent estrogen action on the liver. The mechanism of estradiol-induced uterine and hepatic glycogenesis as well as the mode of estrogen-clomiphene interaction are discussed.