Judy, M. M. ; Maithews, J. L. ; Newman, J. T. ; Skiles, H. L. ; Boriack, R. L. ; Sessler, J. L. ; Cyr, M. ; Maiya, B. G. ; Nichol, S. T. (1991) In vitro photodynamic inactivation of herpes simplex virus with sapphyrins: 22 π-electron porphyrin-like macrocycles Photochemistry and Photobiology, 53 (1). pp. 101-107. ISSN 0031-8655
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1751-...
Related URL: http://dx.doi.org/10.1111/j.1751-1097.1991.tb08473.x
Abstract
The photodynamic inactivation of HSV-1, a virus having a membranous envelope, with both a decaalkyl sapphyrin and its dicarboxy-substituted analog was studied. The decaalkyl sapphyrin was as efficient in the inactivation of HSV-1 on a per macrocycle basis as DHE, whereas the efficiency of the dicarboxy-substituted sapphyrin was approximately two orders of magnitude less. Fluorescence studies of sapphyrin's binding to liposomes and VSV suggested that the decaalkylsapphyrin bound monomerically to cholesterol-rich regions of the viral envelope, whereas its charged analog localized in a more polar environment.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| ID Code: | 31956 |
| Deposited On: | 31 Mar 2011 09:59 |
| Last Modified: | 09 Jun 2011 09:50 |
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